Analysis of Biological Networks: Transcriptional Networks - Promoter Sequence Analysis

Each cell of an organism contains an identical copy of the whole genome. However, different tissues have different functions, which means that each cell utilizes only a subset of its genes. The process in which the cell controls the activation of a subset of genes is called gene regulation. Gene regulation can occur at different time points along the gene expression process, including chromatin organization, transcription, premRNA processing, translation and post-translational modifications. Primarily it occurs at the transcriptional level. This lecture focuses on computational approaches to decipher transcriptional regulation.